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Showing 1 to 12 of 261 entries
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Sex differences in the prognostic significance of KRAS codons 12 and 13, and BRAF mutations in colorectal cancer: a cohort study.

Biology of sex differences

Wangefjord S, Sundström M, Zendehrokh N, Lindquist KE, Nodin B, Jirström K, Eberhard J.
PMID: 24020794
Biol Sex Differ. 2013 Sep 10;4(1):17. doi: 10.1186/2042-6410-4-17.

BACKGROUND: Activating KRAS and BRAF mutations predict unresponsiveness to EGFR-targeting therapies in colorectal cancer (CRC), but their prognostic value needs further validation. In this study, we investigated the impact of KRAS codons 12 and 13, and BRAF mutations on...

Sexual dimorphism in the hypophysiotropic tyrosine hydroxylase-positive neurons in the preoptic area of the teleost, Clarias batrachus.

Biology of sex differences

Saha S, Patil S, Singh U, Singh O, Singru PS.
PMID: 26557978
Biol Sex Differ. 2015 Nov 09;6:23. doi: 10.1186/s13293-015-0042-x. eCollection 2015.

BACKGROUND: Dopamine (DA) neurons in the anteroventral periventricular nucleus (AVPV) in the preoptic area (POA) of mammals express estrogen receptors, regulate luteinizing hormone (LH) secretion, and show distinct sexual dimorphism. In teleosts, hypophysiotropic DA neurons of the nucleus preopticus...

Human umbilical endothelial cells (HUVECs) have a sex: characterisation of the phenotype of male and female cells.

Biology of sex differences

Addis R, Campesi I, Fois M, Capobianco G, Dessole S, Fenu G, Montella A, Cattaneo MG, Vicentini LM, Franconi F.
PMID: 25535548
Biol Sex Differ. 2014 Dec 14;5(1):18. doi: 10.1186/s13293-014-0018-2. eCollection 2014.

BACKGROUND: Human umbilical endothelial cells (HUVECs) are widely used to study the endothelial physiology and pathology that might be involved in sex and gender differences detected at the cardiovascular level. This study evaluated whether HUVECs are sexually dimorphic in...

Neonatal outcomes in relation to sex differences: a national cohort survey in Taiwan.

Biology of sex differences

Weng YH, Yang CY, Chiu YW.
PMID: 26664663
Biol Sex Differ. 2015 Dec 09;6:30. doi: 10.1186/s13293-015-0052-8. eCollection 2015.

BACKGROUND: An extensive assessment investigating the association between sex differences and neonatal outcomes is lacking. In the current study, we estimated the correlation of gender with adverse birth outcomes in a large cohort population.METHODS: National population-based data containing maternal...

Sex differences in autonomic function following maximal exercise.

Biology of sex differences

Kappus RM, Ranadive SM, Yan H, Lane-Cordova AD, Cook MD, Sun P, Harvey IS, Wilund KR, Woods JA, Fernhall B.
PMID: 26629325
Biol Sex Differ. 2015 Dec 01;6:28. doi: 10.1186/s13293-015-0046-6. eCollection 2015.

BACKGROUND: Heart rate variability (HRV), blood pressure variability, (BPV) and heart rate recovery (HRR) are measures that provide insight regarding autonomic function. Maximal exercise can affect autonomic function, and it is unknown if there are sex differences in autonomic...

Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.

Biology of sex differences

Johansson MM, Lundin E, Qian X, Mirzazadeh M, Halvardson J, Darj E, Feuk L, Nilsson M, Jazin E.
PMID: 26759715
Biol Sex Differ. 2016 Jan 12;7:5. doi: 10.1186/s13293-015-0056-4. eCollection 2016.

BACKGROUND: Renewed attention has been directed to the functions of the Y chromosome in the central nervous system during early human male development, due to the recent proposed involvement in neurodevelopmental diseases. PCDH11Y and NLGN4Y are of special interest...

Sex-related differences in pain behaviors following three early life stress paradigms.

Biology of sex differences

Prusator DK, Greenwood-Van Meerveld B.
PMID: 27293543
Biol Sex Differ. 2016 Jun 10;7:29. doi: 10.1186/s13293-016-0082-x. eCollection 2016.

BACKGROUND: Early life stress (ELS) serves as a risk factor for the development of functional pain disorders such as irritable bowel syndrome (IBS) in adults. Although rodent models have been developed to mimic different forms of ELS experience, the...

Early androgen exposure and human gender development.

Biology of sex differences

Hines M, Constantinescu M, Spencer D.
PMID: 25745554
Biol Sex Differ. 2015 Feb 26;6:3. doi: 10.1186/s13293-015-0022-1. eCollection 2015.

During early development, testosterone plays an important role in sexual differentiation of the mammalian brain and has enduring influences on behavior. Testosterone exerts these influences at times when the testes are active, as evidenced by higher concentrations of testosterone...

Evaluating sex as a biological variable in preclinical research: the devil in the details.

Biology of sex differences

Tannenbaum C, Schwarz JM, Clayton JA, de Vries GJ, Sullivan C.
PMID: 26870316
Biol Sex Differ. 2016 Feb 11;7:13. doi: 10.1186/s13293-016-0066-x. eCollection 2016.

Translating policy into action is a complex task, with much debate surrounding the process whereby US and Canadian health funding agencies intend to integrate sex and gender science as an integral component of methodological rigor and reporting in health...

Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner.

Biology of sex differences

Elderman M, van Beek A, Brandsma E, de Haan B, Savelkoul H, de Vos P, Faas M.
PMID: 27051505
Biol Sex Differ. 2016 Apr 05;7:21. doi: 10.1186/s13293-016-0075-9. eCollection 2016.

BACKGROUND: Males and females have a different predisposition for the development of intestinal disorders, like inflammatory bowel disease (IBD). We hypothesized that sex specific differences in intestinal immune responses may underlie this bias. To test this hypothesis, we studied...

Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice.

Biology of sex differences

Quinnies KM, Bonthuis PJ, Harris EP, Shetty SR, Rissman EF.
PMID: 25987976
Biol Sex Differ. 2015 Apr 28;6:8. doi: 10.1186/s13293-015-0026-x. eCollection 2015.

BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh...

A comparative study of renal function in male and female spiny mice - sex specific responses to a high salt challenge.

Biology of sex differences

Dickinson H, Moritz KM, Kett MM.
PMID: 24321563
Biol Sex Differ. 2013 Dec 10;4(1):21. doi: 10.1186/2042-6410-4-21.

BACKGROUND: There is a significant body of evidence to suggest that hormone levels, receptor density and structural differences between males and females can significantly alter renal hemodynamics. We compared the renal hemodynamic and excretory profile of female and male...

Showing 1 to 12 of 261 entries